Difference of Endometrial Thickness and Vascularity in Women Stimulated by Clomiphene Citrate with and without Vitamin C and E

Objective: To observe the effect of vitamin C and E administration on endometrial thickness and vascularity in clomiphene citrate stimulated endometrium Method: Research design was randomized clinical trial. Both groups were stimulated with clomiphene citrate. Treatment group was given vitamin C and E, while control group was given placebo. Transvaginal ultrasound examination is used to assess endometrial thickness and vascularity (resistance index/RI) in cycle day 2 and 12. The difference between two groups is tested with independent t and Mann-Whitney test. Result: A total of 38 subjects was included as research subjects. Endometrial thickness in treatment and control group have cycle day 12 means of ±8.89 and ±5.9 mm, respectively. In the first and latter group were found differences of 60.76% and 27.26%, respectively. MannWhitney test showed very significant difference p=0.000 (p<0.05) between endometrial thickness in treatment and control group. Endometrial vascularity between treatment and control group have cycle day 12 RI means of ±0.51 and ±0.52. In the first and latter group is found differences of -13.52% and -11.07%. Independent t test showed no significant difference p=(0.217) between treatment and control group. Conclusion: Endometrium stimulated with clomiphene citrate and addition of vitamin C and E is thicker compared to control group. No significant difference on endometrial vascularity stimulated by clomiphene citrate with or without vitamin C and E.